Salt Retention Hormone a Greater Factor In African American High Blood Pressure

Hypertension, or illustrious blood constant worry, be 50 percent
more prevalent in African Americans than in Caucasians, and
saline retention may be a potent contributor to this high rate
among African Americans. Aldosterone is an adrenal hormone that
present salt-retention beside the kidney. A topical analysis by
squad at the Medical College of Wisconsin and the University of
Montreal, Canada offer a key group relating intricate level of
this hormone and high blood pressure in
African Americans.

The teams rough sums wakeful to aldosterone levels in fraction to
blood pressure in two definite genetic populations:
Milwaukee-area African Americans, and a squadron of
geographically and genetically isolated French Canadians.
Participants experience biological assessment, medical history
and 24-hour in-patient vdu of blood pressure and blood chemistry,
with plasma aldosterone, while supine and by the side of two
legs.

Over 1,000 applicant of Milwaukee's African American municipal
enjoy chip in to this ongoing research at Froedtert Hospital, and
more volunteers be needed.

The study be organize by Theodore A. Kotchen, M.D., general
prologue dean in support of clinical research and professor of
prescription at the Medical College, and Pavel Hamet, M.D.,
Ph.D., at the University of Montreal. Their abstract appear in
the October 2004 dynamic of Hypertension, where on earth the
bursting manuscript have be agreed for publication presently.

The researchers chitchat that blood levels of aldosterone are
higher in African Americans with high blood pressure than
in Caucasians, and that within is a notably significant
correlation between blood levels of aldosterone and blood
pressure in African Americans. In an in advance study, they also
found that elevated aldosterone is uniformly matching to
over-development of the departed ventricle of the heart in
African Americans with high blood pressure.

These observations may thorn the path to medication apparition
therapy that would be markedly gainful for African Americans with
high blood pressure, according to Dr. Kotchen. "Specifically, we
could see the future that drugs that traffic jam the salt retain
effect of aldosterone in the kidney would be particularly
forceful agents to degrade blood pressure in hypertensive African
Americans," he right to be heard.

Ongoing, parallel research in indication model of hypertension by
Allen W. Cowley Jr., Ph.D., chairman and professor of physiology
at the Medical College, may also abet identify which patients
with high blood pressure would godsend record from these new
therapies. Dr. Cowley, administrator of the National Specialized
Center of Research on the Molecular Genetics of Hypertension, is
functional to translate the genetic code of salt-sensitive rats
built-up in his laboratory to the human genome.

The human study are support by grant from the National Institutes
of Health (NIH), and conduct by Medical College researchers in
the NIH fund General Clinical Research Center at Froedtert
Hospital in Milwaukee, and by University of Montreal Preventive
and Community Genomic Medicine Center researchers at Chicoutimi
Hospital in the Saguenay-Lac St. Jean county of Canada.

African Americans may be eligible to join here research if they
have high blood pressure and are ages 18 to 55, or if they have
middle-of-the-road blood pressure and are ages 30 to 55. They
cannot have diabetes, be expectant or
morbidly obese.

Medical College of Wisconsin 8701 Watertown Plank Rd.

Milwaukee, WI 53226 Phone 414-456-4700 Fax 414-456-6550

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