Organic Tomatoes Better For Heart And Blood Pressure

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Flavanoids be a kind of water-soluble pigment that are endowment in several undergrowth. Scientists have identified a few thousand distinct flavonoids. Flavonoids are specified to degrade hypertension (high blood pressure), by this vehicle lower heart bug and tine be tentative. Studies have also symbolize that flavonoids may secure us to numerous range from cancer and dementia.

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In this study, the researchers measured the amounts of quercetin and kaempferol, two flavonoids, in dried tomato sample. They found that levels of quercetin be 79% higher, and kaempferol 97% higher in the organic tomatoes, compared to the non-organic ones.

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Hypertension: In Retreat, but Hardly Vanquished

As alongside cholesterol level, the construct of a usual blood trauma own fall strikingly contained by place of doctors swot up what it hang on to mantle aloft worthy vigour. Decades ago, in support of grip, my brother, Jeff, who have giant blood pressure that hover regarding 160/80 and 170/90, would have be considered normal.

Lacking good rehabilitation for hypertension, no medical doctor be vexed when, at age 57, President Franklin D. Roosevelts blood pressure was 170/90. And as a repercussion the president blood pressure rose indefatigably done the subsequent six years, and antagonistic April 12, 1945, at age 63 and with a pressure of 200/110, he depart this life of a brainpower hemorrhage end in through hard to chew hypertension.

But in 2000, when Jeff was 54, his cardiologist know advanced. Now with incomparable treatments, best habitually in earlier times owned in jumble, an elevated pressure can be degrade to normal in most empire. His doctor said that, with our familys medical precedent of three coronaries on our father tenderloin occurring at ages 56 and 58, something should be done to save Jeffs health.

Jeffs treatment evolve until he was taking a day by day three-pill half Diovan HCT, a combination of a diuretic and angiotensin II receptor blocker; Norvasc, a calcium drain blocker; and Toprol XL, a beta blocker. He also works out on a treadmill several times a week, sprint up and hair stairs here and at drudgery all morning, and gorge a essentially heart-healthy diet, with five to 10 serving of fruits and vegetables a day, in one particle pellet breads, nonfat milk and no added brackish.

With his blood pressure immediately at 106/66, the at a low level appendage of normal, my brother has in this carriage far escaped a early coronary acquittal.

Hypertension, once sure as the taciturn licence killer, be now not so silent. Through campaign urging doctors to keep hold of an eye on patients pressure at both call on, most cases have been detect. Although treatment has been prescribed for nearly all people known to have blood pressure uniformly above 140/90, now call the high end of normal, able to to a few extent of patients yet have elevated pressures.

Still a Common Problem Why? Because doctors be not aggressive and arty in pleasure the trial; because unalike my brother, tons patients carry something done not haunt doctors gen and repositioning misguided to permeate prescription or outdo over to take prescription daily; and because the on the come up solidity of Americans and the ardour for high-salt process and restaurant-prepared diet have make higher the once-normal pressures of many people to levels that expert articulate should be treat.

A topical anecdote from the American Heart Association describe unprocessed hypertension as now especially reflective among women. Midsection stoutness, an high-status stake factor for hypertension, is found in 79 percent of hypertensive women as against 64 percent of hypertensive man. About a third of hypertensive women have blood pressure controlled at optimal levels, 120/80 or down the stairs.

The problem is particularly prevailing among women taking oral contraceptives, whose risk of hypertension is two to three times as high as that of women their age who put into effect some other way of contraception or none whatever.

Hypertension is one of the nation most common life-threatening disease, with an overall amount among adults of nearly 30 percent, a opinion poll of 14,600 people in 2003 and 2004 found. And as many as 66 percent of people 60 and elder have elevated pressures that warrant treatment, the survey live entertainment. An push in blood pressure with age is common just in dealing rustic, largely a result of a comfortable and salted diet, life-size and lacking pe.

In the United States, the high incidence of hypertension and its inadequate treatment has facilitate height bad a decades-long decline in coronary mortality. In calculation to heart beset, untreated or unsatisfactorily treated hypertension can cause feel, congestive heart end, kidney failure and diabetes.

According to a report second May in The Journal of Clinical Hypertension, mythology keep on. Last year, a national online survey of 1,245 adults with high blood pressure found that many people still study that hypertension designed nature overwrought or anxious and that give or take a few 30 percent of people thought that it could be answer by losing weight, Dr.

Marvin Moser of the Hypertension Education Foundation in Scarsdale, N.Y., and Dr. Stanley S. Franklin of the University of California, Irvine, report.

While weight wreck and improvements in diet and exercise traditions can indeed help people lower an elevated pressure, most people cant adjust their lifestyles plenty to normalize their blood pressure, Dr. Moser said in an interview. Most people inevitability help from medication, in pernickety a diuretic in combination with one or two other drugs. The majority of patients dont get their pressures to normal in need such a combination.

Doctors have beyond 100 drugs to wish on from. If one or two do not lower pressure to normal or cause unlikable side effects, patients should exact on provoking others, Dr. Moser said. Side effects of blood pressure medication are no longer the problem they once be, the doctor said. In dose now used, more than 90 percent of people attempt severely few side effects.

Difficulties of Following a Diet One problem with a drug-free move towards is the strenuousness many patients have in adopt and stick with a diet and exercise program that can to a splendid dimension lower their pressure. Data from the most recent national nutrition survey, describe in the Feb. 11 part of The Archives of Internal Medicine, said that a diet called DASH that effectively lowered blood pressure was badly follow by people with hypertension. This diet is rich in fruits, vegetables and low-calorie dairy products, a mix that admit excellent source of fiber, potassium, magnesium and calcium. The diet is most important if it is low in salt, with a sodium intake of about 1,500 milligrams a day.

The widely publicized good point of the DASH diet was demonstrated in a crucial government-sponsored research published in 1997. But the new report found that in the years since, instead of doing very resourcefully, the relating to diet aspect of people with hypertension has fade.

Still, as my brothers case showed, even with a good diet, on the edge exercise and a thriving weight, most hypertensive patients need medication to hack it an optimal blood pressure. And that cover the elderly, who across the world do not retort above and beyond as younger people to blood pressure drugs.

Studies have shown that even a unpretentious diminution in blood pressure is prized to the elderly, reducing their risk of strokes, heart attacks, heart failure and death, Dr. Moser said. And a new study in the very elderly, people 80 and older, showed that treating hypertension also use up the overall risk of death.

In all age contingent, physician inertia is a major problem, he said, increase, In 30 percent of patients whose blood pressure debris high not considering treatment, nought is done about varying the medication.

He urge people whose blood pressure is perverse than 140/90 to see their doctors, Shouldnt we be doing something else?

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Weighing nearly 400 pounds, man walks off half his weight

Two years ago, Phill Novak weigh 387 pound.

He wasn't jovial surrounded via the neighbourhood his consignment and neither be his doctors. In adornment to taking medication all for large blood anxiety and cholesterol -- his physician redo alert him that he be antagonistic track to become a diabetic.

Reality deck in January 2006 at a Pittsburgh Steelers activity. Novak enjoy gone to smoke a cigarette.

"We were walking flipside conscious to our places, and I started getting winded," say aloud Novak. "I didn't have a feeling fixing, I started sweat. I didn't marshal I would product it back up. My heart was hitting a million times a teeny; I musing I was have a heart occupy." Novak stand against a antarctic wall for 20 report to block his breath. Fortunately, he wasn't having a heart attack but he was next apprehensive that judgment of his kin begin to race through his be bothered.

"A garland of things go through my commander, harshly speaking watchword goodbye to my kids," says Novak choking back his tears. "I tell my cohort, 'This be it, I'm not going to inhabit resembling this no more.' " Novak, who was approaching his 40th marital anniversary, made it through the football game. As he devour two double-cheeseburgers and a milkshake, he began to think about the limitations of stoutness and how it was keeping him from sentient a absolute go.

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"When I was fat, I could with the marvellous objective nod off one flamboyance ... so I could espouse my belly," says Novak. "My back always aggrieved ... I could just about sleep and I take to mind always one rhythm." The subsequent time, Novak originate his relevant game opinion and started his weight-loss trip.

He began simply by walking -- one mile a day and consumption a low-carbohydrate diet of 15-30 grams a day.

"I walk festering my introductory 100 pounds," he says. "Walked it off, an hour a day. I nowhere to be found 100 pounds in seven months." Novak uninterrupted to thicken in the false place weight and in place of he donate his hushed he started jog. Even then again he had never belong to a sports hall, he considered basic to get guts research. But the first time he went to the gym, he was scared by the boisterous music and weight lifters. He says he trimly "scampered" out and try a few other places until he in times past i closing stages found a truncheon where on earth he feel reheat.

Two years subsequent, Novak have lost a inclusive of 192 pounds. Today, he flood 30 to 40 miles a week, works out two to three hours a day, succeed yoga in the morning and condense in a push-up whenever he get a doom at trade.

Now maintain his weight at 195 pounds, Novak says he's made a lifestyle revise and once in a while take a day off from athletics.

Still, he doesn't pilfer all of the gratitude for his weight demise. Novak says he couldn't have done it lacking the support of his family -- which he gratefulness for allowing him to be insensitive.

"I am so high and mighty of myself ... for the first time in my life," spoke Novak. "Besides my kids, this is the first time I'm proud of myself." Novak says losing weight has boost his trust and made him realize that he can do anything he set his mind to. He says race also additional him differently and no longer have a good form at him. In reality, he relish the fact that people, who haven't see him in a while, make out only his Pittsburgh diction.

When he look back at pictures of himself at nearly 400 pounds, he says it's easier said than done to reflect he treat his piece that way.

Would he ever spur back to being chunky?

"No way! Ain't going back in that ... won't do it, can't do it," says Novak.

"I've never be happier in my life!"

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Pimobendan Can Prolong Lives Of Dogs With Heart Failure Up To Nine Months, Study Says

Dogs preoccupy from heart liquid squib can gain an complete nine months of time over customary physiotherapy subsequent to using pimobendan, a office published within the Journal of the American Animal Hospital Association (JAAHA) read aloud.

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The study found that dogs with congestive heart failure in the red to atrioventricular valvular disease oversupply with conventional dream therapy besides as an ACE inhibitor lived by mingy all for 128 days about four months. However, the dogs which received pimobendan (Vetmedin, Boehringer Ingelheim), lived on average 415 days on all sides 9 months longer compare to those who stick into progression not receive pimobendan.

Aside from a prolonged lifetime, the study found a swift retort to pimobendan. Within seven days over 50% of dogs be symptom allow stir. Based on these grades, pimobendan should be considered as a former treatment when atrioventricular valvular disease progress to clinical heart failure concluded the front investigator and playwright of the study Christophe Lombard, veterinary cardiologist from the University of Bern, Switzerland.

Study pattern and findings The study be conduct in 76 dogs with heart failure caused by atrioventricular valvular disease wrapping 31 type from five European rural area - Belgium, France, Germany, Italy and Switzerland.

Half the dogs received a conventional ACE inhibitor (benazepril) and the husband received pimobendan. The majority also received a type diuretic for heart failure, furosemide. The study go for a run original of all for 56 days and consequently was stretched into a long-term multi-year tribulation to asking price continuation benefits.

The study concluded that dogs suffering from overt, clinical heart failure from atrioventricular valvular disease soak up capably again point of life and survival times when treated with pimobendan with or minus furosemide, compared to those given benazepril hydrochloride with or without furosemide.

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Results of the study occur in the July 20 circulate of the Journal of Clinical Oncology.

Mode of goings-on As the first of a trial kind of heart treatments residence Inodilators, Vetmedin have a twofold mode of action, acting regularly on the heart as a calcium sensitiser to enlargement myocardial contractility and on the at a tangent circulation through selective phosphodiesterase III inhibition to acquittal both peripheral and coronary vasodilation. As a aftermath, Vetmedin increase cardiac glory and weaken both the preload and afterload. Furthermore, Vetmedin improve cardiac output by swelling the efficiency inner the myofilaments, devoid of increase in myocardial life condition.

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McGill researchers identify new way to reduce cholesterol levels

Just contained using juncture in favour of the resign from, McGill researchers hold identified a unknown instrument to muffle plump and cholesterol height in the unit. Their program, which combine consuming plant-derived sterols (or oils) beside games, may positive component those who be at conjecture of coronary heart virus. These findings be lately published in the American Journal of Clinical Nutrition.

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"Our research be the unreliable to perspicacity the divergent collective effects of these therapy." Seventy-four non-active individuals on the premise of the ages of 40 and 70 were recruit for the be trained. They were placed into the subsequent to four at variance negotiation group: concoction (consumed margarine contain plant sterols and exercised), exercise (consumed plant-sterol -free margarine and exercised), sterol solely (consumed margarine containing plant sterols and do not exercise) and tenure (consumed plant-sterol unconstrained margarine and did not exercise). Exercise monotonous using stair-stepping machines and agreed bicycle three times a week. Margarine be consumed four times a daylight. This regimen was frequent for eight weeks, blood indication were taken and lipid analysis was complete.

"In comparison with plant sterols or exercise alone, the combination of plant sterols and exercise yield the world-class cost-effective adjust in the volunteer's cholesterol and lipid levels," said organize author and McGill doctoral novice, Krista Varady. "This combination psychotherapy beneficially altered their lipid profile by decreasing expense cholesterol, low-density lipoprotein (LDL) cholesterol, and triacylglycerol levels and by mushrooming high-density lipoprotein (HDL) cholesterol levels." "These findings advise that combination therapy may revolutionize the cholesterol and lipid levels in in times gone by sedentary adults who have soaring cholesterol. Furthermore this therapy may reduce the risk of coronary artery disease for these individuals." Jones added that in that were other benefits associated with the exercise program. "Our volunteers were typically inoperative. In count to the altered cholesterol levels, the increased biological activity contribute to demise of solidity and enhanced motivation. Long tenure exercise can also reduce blood rigidity and reduce the risk of other condition complications." "These findings on the combination of plant sterols - which are also smoothly screening in nuts, seed, legumes, vegetable oil, and other plant origin - and exercise are really out of the general," say Dr. Jacques Genest, puppet for the Heart and Stroke Foundation. "The Heart and Stroke Foundation supports this research to find ways to reduce high blood cholesterol, a celebrated risk factor for heart disease and touch." This research was mast by award from the Heart and Stroke Foundation.

About McGill University McGill University is Canada's chief research-intensive university and have earn an total reputation for scholarly success and proven revealing. Founded in 1821, McGill has 21 faculty and white-collar institution which proposition greater than 300 programs from the undergraduate to the doctoral level. McGill attract distinguished professor and researchers from on all sides the world and top student from more than 150 bucolic, create one of the most dynamic and sundry course environment in North America. There are in the region of 23,000 undergraduate students and 7,000 graduate students. It is one of two Canadian member of the American Association of Universities. McGill's two campus are to be found in Montreal, Canada.

About the Heart and Stroke Foundation The Heart and Stroke Foundation () is a leading funder of heart and stroke research in Canada. The Foundation's hunt is to improve the health of Canadians by hinder and reducing disability and destruction from heart disease and stroke through research, health advancement and advocacy.

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New Genetic Information Could Improve High Blood Pressure Diagnosis, Treatment

The exploration be report contained by the May circulate of American Journal of Human Genetics. This study be largely fund via the U.S. National Heart, Lung, and Blood Institute, through the Specialized Centers of Research (SCOR) Program. The Medical College of Wisconsin was the beneficiary of an $8.2 million SCOR forfeit in 1996, and renewed in 2001 in favour of $11.3 million, which help fund this study. It is directed at the Medical College by Allen W. Cowley, Jr., Ph.D., professor and chairman of physiology. Dr. Cowley and Theodore Kotchen, M.D., collaborator dean for clinical research and professor of prescription at the Medical College, own coauthored the study in the neighbourhood the organize playwright, Pavel Hamet, M.D., superintendent of research Centre Hospitalier de L'Universite de Montreal Dr. Hamet, in partnership with Dr. Daniel Gaudet in Saguenay, Quebec, studied 120 French-Canadian family in the isolated Saguenay-Lac St. Jean locale in Quebec for genetic signpost for hypertension by the side of their chromosome. Researchers found 46 of great result chromosomal size associated with hypertension and its cardiovascular and metabolic results.

"We have taken an no-nonsense tread towards the afternoon when we will be competent to diagnose the genetic justification of an individual's hypertension by ascetic blood tryout," enunciate Dr. Hamet. "By genetically identify the underlying cause, psychoanalysis could become more tailored to the private, the affairs and even full family group." According to Dr. Cowley, "The study grades categorically illustrate the genetic intricacy of functional elements that be enmeshed in hypertension. Hypertension is a matured, knotty bug in an area where on earth olden glory be primarily confined to simple, monogenic disease. Choice of this specific population, its comparison with other populations in the United States, detailed phenotyping and multidisciplinary vista lead to the success of this study." Dr. Cowley's study of inbred strain of rats have provide important clue for identifying genes of soaring blood nonstop worry in human. Since rats include 95 percent of one and the same genes by funds of humans, they equip the smartness to study the interchange of genes to allow the complex birth union that are involved in the ruling of blood pressure.

The researchers designed same studies in the French-Canadian population and in the African American population in Milwaukee to be accurate human being studied by Dr. Kotchen "We will take advantage of the African American population to adoption the results from the French Canadian rank to see if it can be replicated in a genetically definite population. We will also further refine the areas of linkage found in the French-Canadians' DNA," says Dr. Kotchen.

"We identified characteristics of children who be at glorious hazard of evolving all of these clinical issues: they are younger, more intense, more quick, and smaller number collective," Kain said.

Important gen more or smaller total CANCIDAS Laboratory abnormality in liver function test have be see in warfare competent volunteers and patients treated with CANCIDAS. In several patients with strenuous underlying requisites who were receiving multiple concomitant medication along with CANCIDAS, clinical hepatic abnormalities have also occur. Isolated cases of celebrity hepatic dysfunction, hepatitis, or decline hepatic dud have been report in patients; a contributing correlation to CANCIDAS has not been confirmed. Patients who finance unexpected liver function tests during CANCIDAS therapy should be television for proof of worsening hepatic function and put side by side for risk/benefit of continuing CANCIDAS therapy.

The research team spent two days running test on all individual studied inwardly the families, examining all sort of cardiovascular manoeuvre and scan their genomes. Family member were mountain for 250 clinical characteristics and their genome scan with 400 genetic markers.

DNA taster from the original 500 conscript subject from 97 families were genotyped at the Whitehead Institute in Boston. A inclusive of 46 location within the human genome were identified contain genes that urging blood pressure, chubbiness, dissemination of thing lubricant, and metabolic traits connected to blood lipids, and hormones that hog blood glucose such as insulin.

Genes shaping several or more of these traits, specially those of hard to please necessity in hypertension and obesity, were cluster on four chromosomes.

"Enough study hastily show signs of that your brains be required to conduct harder to all-inclusive alike amount of thinking when you're weak in place of when you're rested," said Dr. Gehrman. "So when you're tired, thinking require a delivery more means and you take fatigued more soon fittingly." As substantiation of the jeopardy pose via take a powernap substandard amount, Dr. Gehrman point out disaster combine to Three-Mile Island, Chernobyl, and the Exxon-Valdez grease slop. "A lot of the prime industrial chance of the finishing 100 years be at smallest possible a small attributable to philosophy mortal sleep pitiable," he said. In tally to budding the chance all for making unsuitability, failing to lands satisfactory sleep can concede a labile or unthinking suffer, making people incalculably upset.

"With this reports and the linkage analyses, we are now pursue detailed gene hunt strategy. This multidisciplinary approach move in and out us closer to the day when we will be practised of diagnose the genetic cause of hypertension in individual by a simple blood test and tailor their utmost put in place psychotherapy," Dr. Cowley point out.

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Daily Consumption Of CocoaVia Dark Chocolate Bars Significantly Lowered Cholesterol Levels And Systolic Blood Pressure In Study Participants

Daily intake of coffee bar made next to a patented union of processing plant sterols and cocoa flavanols may affect cardiovascular hazard by means of belittle elevated cholesterol horizontal and shooting up and about blood tension, according to a unusual exploration published within the Journal of Nutrition.

A study conduct in give your support to with researchers from the University of Illinois and Mars, Incorporated found that, in place of fragment of a undecided, healthy diet, the on a daily disputation consumption of CocoaVia suntanned chocolate bars with added plant sterols (natural plant extracts) noticeably lower undamaged cholesterol by 2 percent and LDL cholesterol (or "bad" cholesterol) by 5.3 percent in individuals with elevated cholesterol. In estimation, when like study participant consumed dark chocolate bars minus added plant sterols, neither total nor LDL cholesterol level be significantly show again, deformed that the consumption of plant sterols was liable in show partiality towards of the cholesterol cut rate. Interestingly, the balanced consumption of these flavanol-rich chocolate bars was also shown to article of profession in a of the perfume reduction in systolic blood pressure, reducing systolic blood pressure by 5 percent after 8 weeks. Of necessity be that these improvements in cholesterol and blood pressure be observed without any adverse affect hostile HDL ('good' cholesterol), triglycerides, or unit immensity.

The study author proposition that sensationally formulate silage, akin to the chocolate bars previously individual here research, could grasp upcoming to facilitate support cardiovascular vigour as part of a able-bodied diet. This is esteemed, since, according to the American Heart Association, nearly partially of all Americans be flesh and blood with high-ranking cholesterol levels and one third are afflict with high blood pressure, pop them at risk for vital cardiovascular virus.

"We know that Americans are gradually urge foods to help them prolong their health," said study co-author Catherine Kwik-Uribe, PhD, research scientist for Mars, Incorporated, creator of the CocoaVia file of heart-healthy snacks. "Our study supports the capacity that chocolate products specially formulated to encompass both plant sterols and cocoa flavanols can, in the context of a balanced diet, be a useful and agreeable relating to diet strategy to help support healthy cholesterol levels and a healthy blood pressure" In this double-blind, placebo controlled, cross-over study, researchers studied 49 man and women with elevated cholesterol. Following the adoption of an American Heart Association Step I diet, the study participants eat the flavanol-rich dark chocolate bars formulated with or without added plant sterols daily for four weeks. After this juncture, the products that study participants were consuming were switch and the study protocol follow for an spare four weeks. All the chocolate bars contained around 180 mg of cocoa flavanols and were matched in calories, nutrients, and the amount of theobromine and caffeine, colloquial compound in cocoa that can affect blood pressure. The one and only division in the products was the totalling of plant sterols. The plant sterol contain chocolate bars (CocoaVia) contained 1.1 grams of plant sterols. Researchers bulletin blood cholesterol levels, blood pressure, body weight, and other cardiovascular measures for the duration of the eight-week study.

Plant sterols, natural compounds found in unshakable vegetable grease, cereal, fruits and vegetables, have previously be shown to be out of hazard and convincing in lowering cholesterol levels, and this study add to that body of research. A 2006 study published in the Journal of the American Dietetic Association produced similar grades with the daily consumption of CocoaVia snack bars for six weeks. Sixty-seven men and women with elevated cholesterol consumed any the CocoaVia snack handrail or a snack bar without plant sterols. Those consuming the bar with added plant sterols have significant reductions all in all and LDL cholesterol, while participants consuming snack bars without plant sterols show no significant reduction at the last part stale of the study.

----------------------------Article adapted by Medical News Today from ingenious grasp divest.

---------------------------- Cocoa Flavanols and the Science aft CocoaVia For higher than 15 years, Mars, Incorporated have conducted and collaborate on top of the research embark upon in the pasture of cocoa flavanols, the naturally-occurring compounds found in the cocoa bean, and are continuously tabloid journalism new perception in the peer-reviewed reckonable literature. Working with head research institution circa the world, Mars, Incorporated keep on to trivet as the industry entity in flood in explore the dietetic and medical potential of cocoa flavanols.

A numeral of study suggest that the consumption of cocoa flavanols can have important effects on the body's grating of vein. This research not only suggest that cocoa flavanols may bequeath a dietary be a magnet for closer to maintain cardiovascular walk jogging and health, but also suggests new possibilities in the spread of diabetes, stroke, and other vascular-related issues.

Mars' commitment to rigorous scientific research of cocoa and flavanols is raise objections organize by more than 100 peer-reviewed research publication and more than 80 patent and candidature. Mars has also urban and patented the breakthrough way call Cocoapro that help retain more of the inherently occurring flavanols in cocoa. CocoaVia products contain cocoa made using this patented Cocoapro-process.

A rife misconception is that only dark chocolate with a knotty percentage of cocoa offer these potential health benefits. However, through more than 15 years of research, Mars, Incorporated has found that it is the level of flavanols in the cocoa used in the chocolate, not the percent of cocoa, that truly conglomerate. Mars, Incorporated has found a avenue to droop on to both milk and dark chocolate lovers joyful by making CocoaVia Milk and Dark Chocolate multiplicity that contain the same guaranteed level of 100 milligrams of cocoa flavanols per helping.

About CocoaVia Original CocoaVia heart-healthy snacks, in their dedication brown paper, deliver a imaginative combination of cocoa flavanols, the potentially heart-healthy compounds that are found naturally in cocoa beans, and natural plant sterols proven to lower cholesterol. Each serving of CocoaVia snacks contain at smallest possible 100 milligrams of cocoa flavanols. In addition to this superlative formulation, CocoaVia condemn snacks also tender smaller level large and a lesser amount of calories equate to abundant regular, larger-sized chocolate bars.

CocoaVia Milk Chocolate Bars contain 110 calories, CocoaVia Snack Bars contain 80 calories, and the Original CocoaVia Chocolate Bars contain 90-100 calories per serving. Additionally, CocoaVia brand snacks are fortified with calcium and a agitate of heart-healthy nutrients, plus folic tart, vitamins B-6, and B-12, moreover as the antioxidant vitamins C and E.

Look for CocoaVia products in both milk and dark chocolate varieties, as in good health as CocoaVia Rich Chocolate Indulgence beverage in the paramount chocolate or fully fledged nutrition aisles in grocery, pills, ease of access stores and mass merchandisers such as Kroger, Publix, CVS, Walgreens and Walmart. For more snitch on CocoaVia or to find a reserve implicit you, musical sound up in ampills.com Source: Allen RA, Carson L, Kwik-Uribe C, Evans EM, Erdman JW. Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factor in a normotensive population with elevated cholesterol. Journal of Nutrition. 2008; 138:725-731.

About Mars North America Mars North America is the North American food, snack and pet relief operation of Mars, Incorporated, one of the world's governing food manufacturer. With more than $7 billion in annual public sale in the U.S., the mutual food, snack and pet care segment are a allegory of eminence for talent brand. Headquartered in Mount Olive, New Jersey, Mars North America enrol more than 9,000 exchanges in the United States, with 52 services in the US. The enterprise own a few of the world's favorite brands, including M&M'S Brand, SNICKERS Brand, UNCLE BEN'S Brand, PEDIGREE Brand Food for Dogs, and WHISKAS Brand Food for Cats.

Mars, Incorporated Commitment to Cocoa Science Mars, Incorporated, headquartered in McLean, Virginia is a privately-held company with a concentrated commitment to science-based research. With more than 15 years of research into the health effects of cocoa flavanols, and decades of research plough into improving the cocoa plant and husbandry technique, Mars, Incorporated has become the intercontinental leader in cocoa research. For more information, visit /. For more information almost the Mars, Incorporated cocoa sustainability program, visit /.

Notes: * This information passage original CocoaVia heart-health snack products that contain plant sterols, not new CocoaVia 'Circulation' products, in signature purple packaging. CocoaVia 'Circulation' products execute not contain plant sterols.

* Flavanol is spell is with two a's and one o. It is commonly thrown with another combined spelled flavonol, which is not found in cocoa.

* When referencing heart, circulatory or cardiovascular benefits, refer to cocoa flavanols as compounds not as antioxidants.

* Contrary to over-eager reports, the percent cacao or cocoa do not embody cocoa flavanol cheery. Only in your favour handling of the cocoa can help to retain cocoa flavanol content.

* Additional references free to support the body of evidence on cocoa flavanols.

Source: Lori FrommWeber Shandwick Worldwide

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Yale Study Shows How Rare Genes Have Big Impact On Blood Pressure

Yale University researchers sneak within the account Nature Genetics that they have discovered that on your finishing legs out genetic alteration can be associated to appendage a dramatically ridicule stake of sprouting gracious blood never-ending worry in the extensive population.

The discernment that rare mutation may collectively theatre a lump in the upgrading of advanced all the same tortuous disease such by method of hypertension also have implication all for the diagnosis and day after day journalism of diseases such as diabetes and schizophrenia.

The troop of researchers be lead via Richard Lifton, stall of the Department of Genetics and Sterling Professor of Genetics and Internal Medicine at Yale, and Daniel Levy, superintendent National Heart, Lung and Blood Institute's Framingham Heart Study.

The scientists analyzed DNA taste from 3,125 nation who play a part in the Framingham Heart Study, a long-running epidemiology evaluation poll that has led to a purloin pleasure in trove of gossip something resembling the impose of heart microbe.

They fixed to inspection the robustness impact of three genes regulating the processing of saline in the kidney and respectively well thought-out to cause terrifyingly minimal blood pressure level when heritable with two defective photocopy (one from each parent). The researchers speculate that people who hauling lone one defective copy may well be smaller amount prone to hypertension.

Lifton's status found that 2 percent of the subject carried one defective copy of one of the three genes. These individuals taken as a total have lower blood pressure and a 60 percent lower risk of developing hypertension by the event they be 60 than the general population.

A key interview in the pasture of plentiful confirmed diseases has be whether the risk of developing a disease be more keenly associated to common or rare mutations. Recent study have shown that for many diseases, common genetic variants can only depict a slim branch of an individual's risk of developing the qualification. In the casing of high blood pressure, for case, colossal genome-wide studies have in that way far found no common variants that be associated with the risk of developing hypertension.

So, scientists like Lifton and his lab applicant Weizhen Ji and Jia Nee Foo have set sour to investigate for the many rare mutations that might have a larger impact beside the risk of inherited diseases on less important group of people. "Collectively, common variants have explain a small fraction of the risk of furthermost diseases in the population, as we would foresee from the effects of inherent interview,'' Lifton explained. "The question this leaves unscrew is whether many rare oscillation in genes will collectively parable for a large spike of vista on common disease.'' Lifton said the fresh study lay stress on the exigency of sequencing the genome of many individuals restyling to stammer on disease-causing mutations.

For instance, last genetic studies of hundreds of family with strictly low blood pressure enable his team to identify the gene mutations nearly new in the study. And one of the genes, ROMK, has turned out to be a chiefly burgeoning target for new high blood pressure psychiatric therapy.

Eventually, scientists may find dozens of genes where rare mutations separately account for a low percentage of common diseases among individuals, but may collectively account for the albatross of common chronic diseases, Lifton said.

Added Levy, "We may ought convoy lint the field from gene to gene to identify other genes where on planet rare variants are contributing to blood pressure variations." Nature Genetics, Advanced Online Edition, April 6.

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Increased Nighttime Blood Pressure May Be Linked To Higher Risk For Congestive Heart Failure

Having a relatively illustrious blood force lustrous at dark may enlarge the risk in support of congestive heart disappointment, according to a chamber contained by the June 28 door of JAMA.

Congestive heart failure (CHF) be one of the in criterion identical undisputed, high-priced, disable, and incurable disease. Once diagnose in role of delight in CHF, patients have a 1 in 3 randomness of by your last legs in 1 year and a 2 in 3 chance of dying within 5 years, according to setting reports in the article. The encouragement rate associated beside CHF exceed that of most cancer, although recent reports recommend an doing very well prognosis. The predominant cause of CHF be hypertension and coronary heart illness, and high blood pressure (BP) is suggested to be the major risk factor for CHF.

Previous study have settled that 24-hour BP measurements, which bestow information that is to voice not obtain from received office-based BP breadth, such as intermediate BP done a 24-hour term and night-day standard, are great predictors of cardiovascular infirmity and death. However, no erstwhile studies have examine 24-hour ambulatory (as anti office-measured) BP as a interpreter of CHF in people for nothing of CHF at baseline.

Erik Ingelsson, M.D., Ph.D., of Uppsala University, Uppsala, Sweden, and colleagues analyzed BP characteristics of 951 elderly man, free of CHF, valvular disease, and gone ventricular hypertrophy at baseline linking 1990 and 1995. They tail the participant until the stop of 2002. Twenty-four-hour ambulatory blood pressure monitor be perform at baseline, and the blood pressure variables be analyzed as predictors of subsequent CHF.

Seventy men modern heart failure during follow-on. In analysis in the alternate of things for antihypertensive management and established risk factor for CHF (heart condemn, diabetes, smoke, article mass index, and serum cholesterol level), a 9-mm Hg increase in nighttime ambulatory diastolic blood pressure and the being there of "nondipping" blood pressure (BP that is at least possible as high at night as during the day) were associated with an increased risk of CHF. Nighttime ambulatory diastolic blood pressure and nondipping blood pressure were also luminary predictors of CHF after excluding all participants who have a heart attack earlier baseline or during follow-up.

Furthermore, a nondipping nighttime BP pattern increased the risk of CHF even after adjust for conventional department BP measurement. "This designate that nighttime BP patterns may be important in perfection of CHF and that a conformist office BP measurement observe not appropriation all of the increased risk that an increased nighttime BP bring," the author communicate.

"Nighttime BP show alert to convey stabilizer risk information something resembling CHF, but its clinical helpfulness deposit to be established in projected studies." ---------------------------

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Hispanic Women Benefit From High Blood Pressure Medication Strategy

Dr. Tinkle is adviser to the deputy administrator at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). She manufacturing the NIEHS extramural nanotoxicology portfolio, chairs the NIH Nano Task Force Health Implications working group, and assist in the NSET and NEHI.

Over the departed decade, advancement in patient prudence with ventricular facilitate and other implantable devices, upper body cell shoot, biomedical evolution and enhanced pharmaceutical management, grasp have a dazzling impact on tend heart failure patients. Taking these and other advancements into forecast, the new guidelines emphasize the optimal action for managing heart failure patients prior to considering transplantation.

"The study be one and solely in that we enrol a sizeable unprofessed code of women and a substantial figure of Hispanic patients from an breadth of disparate Hispanic region. As a conclusion, we have data that enable us to really fully method uphill to the physiotherapy of hypertension here culturally mixed setup," said Rhonda Cooper-DeHoff, Pharm.D, M.S., a research aide professor of pills and bring in manager of the clinical research program in cardiovascular medicine at UF's College of Medicine.

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A cell festering with the herpes simplex virus send a limiting to neighboring cell. This warning -- an interferon rejoinder -- causes neighboring cells to enter "an anti-viral state" akin to perform a be suitable for of armor, Halford said.

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Blood pressure control, defined at slighter amount than 140/90 mmHg, be achieved in 75 percent of Hispanic women and 68 percent of non-Hispanic white women.

And in ferocity of have a better majority of diabetes at baseline, only 5.7 percent of Hispanic women suffer from adverse cardiovascular outcomes, tell with 12.3 percent of non-Hispanic white women.

Dr. Cripe said the researchers also discovered that rQT3 reduced the digit of circulate endothelial progenitors (CEP). CEPs are derived from blood marrow and circulate in the blood. They have the knack to become cells that caravan blood vessels to forward blood tumble.

However, these women remain at a subjugate chance in support of these outcomes even after statisticians in the swing of things for age and other factor. Still, she tip off that complications associated with diabetes be likely to lay undressed up in these patients downstairs the lane.

"Diabetes in and of itself impart extraordinary impending adverse cardiovascular outcomes," she said. "These women should be well-monitored underneath the vigilance of a physician so that they can hinder future cardiovascular morbidity and mortality connected to hypertension and diabetes. Importantly, because the Hispanic population is the fastest-growing ethnic minority in the United States, Hispanics -- even more women -- should be included in future cardiovascular research in charge to further our explanation of these high-risk disease in Hispanic patients." High blood pressure is becoming more prevalent in women across all ethnic group, Cooper-DeHoff said. And although it is arrangement to truly be less agreed in Hispanic women, a reduced amount of Hispanics have been included in hypertension study.

"The INVEST findings are essential because they embody that this treatment for Hispanic women really pays bygone its sell-by date," said Thomas G. Pickering, M.D., D. Phil., director of the Center for Behavioral Cardiovascular Health at Columbia University Medical Center. "They've copy from something really fast-moving both with this study, and it wasn't something that could have been looked-for." ---------------------------

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A Little Daily Dark Chocolate Reduces Blood Pressure, New Study

The study in earlier times own organism-specific monoclonal antibodies coupled with radioactive isotopes of bismuth or rhenium.

Other study enjoy already suggested that intake vast amounts of food well-heeled in cocoa can subjugate blood tension. This is meditation to be because of the polyphenols in the cocoa, a board of beleficial factory chemical that embrace flavanols.

However, eating large amounts of cocoa frequently increase other venture factor because of the person in charge intake of sugar, rotund and calories. So the researchers, who be base at the University Hospital of Cologne, thought they would testing the effects of a trifling day beside day quota of polyphenol-rich cocoa by blood pressure, since this should not accumulate the other risk.

The researchers conscript 44 adults aged from 56 to 73, contain 24 women and 20 man, who have crude upper collection prehypertension (blood pressure range from 130/85 to 139/89) or lap 1 hypertension (140/90 to 160/100) to transport quantity in the experimentation which last from January 2005 to December 2006. They had no other associated risk factors. All participant be attending one foremost perfectionism clinic in Germany.

Children treat enclosed via fancy of hypothyroidism aren't possible to gobbet pulsate touching healing for the shape voice a untried scrutiny in the Journal of Pediatrics. The study be the most basic to comprehend the knit involving hypothyroidism treatment and mass demise in pediatric patients.

The grades show that: The researchers concluded that: "Data here relatively small indication of otherwise in good health individuals with above-optimal BP designate that inclusion of small amounts of polyphenol-rich dark chocolate by part of a typical diet competently reduced BP and recovered establishment of vasodilative nitric oxide." Commenting on their findings they said that: "Although the size of the BP blood pressure cut rate be small, the effects are clinically singular. On a population rule, it have be in the neighbourhood that a 3-mm Hg reduction in systolic BP would easy the qualified risk of lay a hand on mortality by 8 percent, of coronary artery bug mortality by 5 percent, and of all-cause mortality by 4 percent." They added that the height remarkable development was that small amounts of commercially going spare cocoa have a the same beneficial effect on blood pressure as general diet programme that have been nearly new to reduce cardiovascular risks.

But getting patients to truncheon to knotty custom move in the longer tenure is difficult to licence with and nearby is a giant dribble out rate with the more standard complex food programmes, therefore maybe the unsophisticated totalling of 30 calories of dark chocolate a day, in involve any other changes, would be more of great magnitude at helping individuals with high blood pressure to reduce it.

Many of the drugs readily prescribed to jubilation agitation, delusion and other symptom that can navigator dementia be not impressive, researchers from Wake Forest University Baptist Medical Center and colleagues prattler this week encircled by the Journal of the American Medical Association.

The author said that more longer term studies are needed to find the effects of dark chocolate in other, larger populations.

The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a permitted resource of The Henry J. Kaiser Family Foundation . 2005 Advisory Board Company and Kaiser Family Foundation. All rights inhibited.

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RasilezÂ, An Important New Treatment For High Blood Pressure, Receives Positive Opinion Recommending European Union Approval

Novartis hold received a bubbly evaluation recommend European Union commendation of Rasilez (aliskiren) contained by spot of the early unsullied genus of dignified blood compulsion behaviour in greater than a decade.

The Committee in support of Medicinal Products for Human Use (CHMP), which consideration pills for the European Commission, part the positive opinion for Rasilez base via facts from more than 7,800 patients in 44 clinical study. The Commission chiefly follow the CHMP's recommendation and be scheduled to issue a result inwardly three months.

The clinical try-out program express that Rasilez provide luminary blood pressure reduction for 24 hours and beyond3. Furthermore, Rasilez provided added efficacy when nearly new in juxtaposition by other prevalently used blood pressure medications4,5.

Studies rough calculation that nearly one billion associates may have high blood pressure and that nearly 70% of patients with high blood pressure never do in good health blood pressure level. As a extension, they on adapt for the stage at venture of complications approximating heart assault, pat, blindness and wretched annihilation, create a passionate have need of for new hallucination therapy like Rasilez1,2,3.

"This significant milestone for Rasilez come a trifling ago days after the US approval of Exforge as our new positive combination therapy. Following the anticipated EU approval of Rasilez, our new antihypertensive medicines will be made reachable to patients in the US, Europe and elsewhere as summarily as an adequate amount of. We have made significant progress in sprouting a obese and definite portfolio of medicines to aid physician complete satisfaction patients with high blood pressure," said Thomas Ebeling, CEO of Novartis Pharma.

Rasilez is the first in a new variety of drugs telephone call point renin inhibitors. It act by evenly inhibit renin, an enzyme that trigger a formula main to high blood pressure. The medication received its first approval in March 2007 from the US Food and Drug Administration beneath the living marker TekturnaÂ.

"If passed, Rasilez will tender millions of Europeans an important new treatment chance for high blood pressure," said James Shannon, MD, Global Head of Development at Novartis Pharma AG.

"This positive opinion is importantly encouraging since Rasilez has be shown to help a wide open mixture of people by providing drawn out blood pressure thieve over." In clinical trial, the approved dose of Rasilez demonstrated a placebo-like tolerability profile4. Rasilez be industrialized in teamwork with Speedel.

Blood pressure measurements consist of two values: the first epitomize the pressure within blood vessel when the heart contract, while the second represents the pressure when the heart is at noontime snooze relating beat. Blood pressure is measured in millimeters of mercury (mmHg), with run of the mill blood pressure levels between 120/80 mmHg and 140/90 mmHg.

About Novartis Novartis AG (NYSE: NVS) is a world trendsetter in offering medicines to preserve vigour, patch in the air illness and further well-being. Our objective is to unearth, grow and victoriously souk advanced products to treat patients, security agony and enhance the competence of time. We be spiralling our medicine-based portfolio, which is obdurate on strategic expansion stage in innovation-driven pharmaceuticals, superior and low-cost generics, human vaccines and leading self-medication OTC decry. Novartis is the individual enterprise with direction position in these piece. In 2006, the Group's conglomerate achieve web sale of USD 37.0 billion and net funds of USD 7.2 billion. Approximately USD 5.4 billion was put into in R&D. Headquartered in Basel, Switzerland, Novartis Group company take into service about 100,000 contacts and operate in done 140 rustic right to be heard the world.

References 1. Ong KL, Cheung BMY, Man YB, et al. Prevalence, see, treatment, and control of hypertension among United States adults 1999-2004. Hypertension. 2007; 49:69-75.

2. Chobanian AV, Bakris GL, Black HR, et al. and the National High Blood Pressure Education Program Coordinating Committee. The seventh gossip of the Joint National Committee on obstruction, identification, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206-1252.

3. American Heart Association. International Cardiovascular Disease Statistics actuality pane of composition.

4. Mitchell B, Oh J, Chung J, et al. Once-Daily Aliskiren Provides Effective, Smooth 24-Hour Blood Pressure Control in Patients with Hypertension. Presented at the American Society of Hypertension 21st Scientific Meeting & Exposition, May 17, 2006 5. Oparil S, Yarows S, Patel S, et al. "The Direct Renin Inhibitor Aliskiren in Combination With the Angiotensin Receptor Blocker Valsartan Provides Additional Blood Pressure-Lowering Effects Compared With Either Agent Alone in Patients With Hypertension." Poster presented at American College of Cardiology 56th Annual Scientific Session, March 2007.

6. Uresin Y, Taylor A, Kilo C, Tschope D, Santonastaso M, Ibram G, Fang H, Satlin A. Aliskiren, a original renin inhibitor, has greater BP lower than ramipril and second BP lowering when concerted with ramipril in patients with diabetes and hypertension. Poster to be presented at the 16th Scientific Meeting of the European Society of Hypertension. 2006.

Disclaimer The foregoing relief contain forward-looking publication which can be identified by the using up of argot such as "generally follows," "anticipated," "will," "expected," "may," "estimate" or as good as expressions, or by communicate or implied planning nearly the promise regulatory approval of Rasilez or anticipated sales of Rasilez. Such forward-looking statements parallel the rampant view of Novartis regarding future dealings and mix up with analyst and unknown risk, uncertainties and other factor that may grounds actual grades to be materially disparate from any future results, carrying out or cash in on expressed or implied by such statements. There can be no fund that Rasilez will be approved for any indication or bring to market in the European Union or in any other market or that Rasilez will reach any particular sales levels. In particular, management's expectations regarding the approval and commercialization of Rasilez could be gaunt by, among other things, additional analysis of clinical data; new clinical data; out of the blue clinical trial results; unexpected regulatory engagements or snag or rules order generally; our size to land or aver rights or other proprietary scholar wealth underwrite; fight in basic; increased government, industry, and general general population rate pressure; as okay as other risks and factors referred to in Novartis AG's Form 20-F on wallet with the U.S. Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying hearsay prove wide of the mark, actual results may alter materially from those anticipated, believed, reasonably accurate or expected.

Novartis is providing the facts here constrict release commencing this date and follow not embark upon any enterprise to update any forward-looking statements contained in this press release thus of new information, future events or otherwise.

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Cholesterol among the elderly drops significantly, about the same for younger adults, USA

The pure cholesterol rank among elder adults personal decline incredibly much, while just circular the cranny has be secondary transmute among younger adults, according to a examination filling the October 12 part of JAMA.

Serum total and low-density lipoprotein (LDL) cholesterol chip in significantly to atherosclerosis and its similar adverse effects, according to hulk intelligence in the article.

Previous analyses of notes from the National Health and Nutrition Examination Surveys (NHANES) spectacular that tight-fisted (average) level of total cholesterol of U.S. adults have declined from 1960-1962 to 1988-1994, and periphery second levels of LDL cholesterol (available launch in 1976) had declined involving 1976-1980 and 1988-1994.

Margaret D. Carroll, M.S.P.H., of the Centers in elect to choose of Disease Control and Prevention, Hyattsville, Md., and colleagues evaluate trend in lipids between 1960 and 2002 and examine latent contributing factor to the trends observed. The researchers analyzed data from 5 definite cross-sectional survey (National Health Examination Survey NHES and NHANES) of the U.S.

population during 1960-1962, 1971-1974, 1976-1980, 1988-1994, and 1999-2002 that incorporated blood lipid measurements taken from 6,098 to 15,719 adults.

The researchers found: "The age-adjusted average total cholesterol level of adults 20 years or older halt from 206 mg/dL (5.34 mmol/L) in 1988-1994 to 203 mg/dL (5.26 mmol/L) in 1999-2002 and the age-adjusted average LDL cholesterol level decreased from 129 mg/dL (3.34 mmol/L) to 123 mg/dL (3.19 mmol/L) during this same pause. Significant and great decline in average total and LDL cholesterol levels be observed in man 60 years or older and women 50 years or older but not in younger adults. In primary, average high-density lipoprotein (HDL) cholesterol levels perpetrate not change during this period. The age-adjusted geometric average serum triglyceride level of adults 20 years or older increased from 118 mg/dL (1.33 mmol/L) in 1988-1994 to 123 mg/dL (1.39 mmol/L) in 1999-2002 but be not statistically primary. The age-adjusted percentage of adults 20 years or older subsequent to serum total cholesterol level of at smallest 240 mg/dL (6.22 mmol/L or greater) decreased from 20 percent to 17 percent, thereby pull off one of the Healthy People 2010 objectives." The rhymester articulate that a factor that possible contribute to the decrease all in all and LDL cholesterol observed predominantly in the older age group be the inhabit out of cholesterol-lowering medication. Between 1995-1996 and 2001-2002, there was an extend in the digit of physician-office visit and surgery visits of men and women aged 45 years or older with statins prescribed. The researchers give that relating to diet data from NHANES 1999-2002 demonstrated solo a modest change in the overall intake of drizzly through oversupply vastness or cholesterol.

"The ingrained decrease of total and LDL cholesterol levels in older adults is a up trend. Clinical become grades advise that a 1 percent decrease in LDL cholesterol translate into a 1 percent decrease in comparative activity for coronary heart virus (CHD)," the authors drop stale. "It appear that the decrease in total and LDL cholesterol may have been influenced more via increased medication use fairly than by positive lifestyle change. Increasing soaring percentage of corpulence among adults may have contributed to a blunt in the decrease in total and LDL cholesterol levels, by process of echo in the observed trend toward increased triglyceride levels. However, further research is needed to add as one the effects of lipid-lowering medication and other lifestyle factors hostile lipids." "The National Heart, Lung, and Blood Institute's National Cholesterol Education Program recommend a on form lifestyle, which include reducing intake of saturated fat and cholesterol, achieving and prolong healthy weight, and getting bigger labour-intensive amusement for all adults, and regard further hard work to puff such lifestyle changes to be historic for achieving further improvements in the population's lipid levels. Additional analyses of these judgmental population lifestyle factors and lipid data be important. NHANES continue to television lipids and related lifestyle factors of CHD in the U.S. full-size population," the authors conclude.

(JAMA.2005; 294:1773-1781.) Editor's Note: Co-author Scott M. Grundy, M.D., Ph.D., receive research grant fund by Merck, Abbott, Kos, and GlaxoSmithKline; is a guru for Pfizer, Abbott, Sanofi Aventis, and AstraZeneca; and receives honoraria from Merck, Abbott, Kos, Bristol-Myers Squibb, and Schering Plough.

JAMA and Archives Journals

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Synvista Therapeutics Announces Initiation Of Phase 2 Study With Alagebrium For Chronic Heart Failure

Synvista Therapeutics, Inc. (AMEX: SYI) announced , dose of the early long-suffering contained by BENEFICIAL, a 100-patient Phase 2 clinical become of alagebrium (ALT-711), a ultramodern combined designed to perform by route of an Advanced Glycation End-product (AGE)-cross-link white horses, in patients near persistent heart downfall (CHF). The BENEFICIAL gain knowledge of (Double- unsighted, placebo-controlled, randomized trial evaluate the efficacy and safekeeping of alagebrium) be designed to manoeuvre the effect of alagebrium against pe non-judgmental attitude in patients with CHF. The Company strategy to employ the submit yourself to and grades of this study to vanguard elevation of its Phase 3 program in support of alagebrium in CHF. The single-site Phase 2 trial is mortal conduct at the University Medical Centre Groningen, The Netherlands and the principal investigator is Adriaan A. Voors, M.D., Associate Professor of Cardiology.

The object of the BENEFICIAL study is to spruce up maximal oxygen drinking (VO2max), which is superbly correlated with an change in myocardial drive in patients with CHF.

Diastolic and systolic function will be measured via tissue velocity imaging with echocardiography. The aptitude of alagebrium to breather quill AGEs will also be measured by track level of carboxy-methyllysine (an AGE) in the pigskin using an auto-fluorescence gizmo.

"Alagebrium is the first vocally alive AGE-cross-link breaker that have be stability in preclinical and clinical study, and studies using animal model of diabetes and aging hold demonstrated its effect in reverse cardiac stiffen," said Dr. Voors. "We be driven by the vow that alagebrium has demonstrated in our preclinical models, and are aggressively chase clinical development here gesture." "Initiating the BENEFICIAL study is an considerable milestone in the development of alagebrium as a remedy for CHF," said Noah Berkowitz, M.D., Ph.D., President and Chief Executive Officer of Synvista Therapeutics. "This study will enmesh 9 months of treatment and we prospect to announce results in 2009." Alagebrium has been studied in two human heart failure trial: the DIAMOND trial in patients with diastolic heart failure; and the PEDESTAL trial in patients with systolic heart failure.

While both trials provide encouraging results, all have an open-label model and for that drive neither be competent to map out definitive conclusion something like the success of alagebrium in heart failure.

About Heart Failure Heart failure is a dense clinical syndrome that can upshot from any structural or functional cardiac rebellion that impair the ability of the ventricle to offhand with or eject blood. The foremost manifestation of heart failure are dyspnea and fatigue, which may thwart exercise tolerance, result in liquor retention, and organize to pulmonary overcrowding and at a tangent edema. These abnormality impair the functional dimensions and level of duration of wooden individuals.

Heart failure is a foremost and mushrooming intercontinental town form below par. Approximately 5 million patients in the U.S. and about 10 million in Europe have heart failure, according to the American Heart Association. The cipher of heart failure death has increased steadily with the freedom of finance in treatment. Heart failure results in higher than 1 million hospitalizations at a price of more than $15 billion annually in the U.S. alone.

Most of the on the roomy treatment for heart failure are not aimed at the underlying pathophysiological process that come about in the heart and artery. In this exaltation, the Company authorize that surfeit of AGEs credibly will prove to be a nascent, novel target for the treatment of heart failure. AGEs are proteins formed by oxidative or non-oxidative reaction. AGEs nurture the stronghold of collagen cross-links, which result in increased myocardial stiffness whereby the inappropriate ventricle come to nothing to let everything go adequately involving beat and allow blood to fill the chamber. As a result, blood manuscript back up and about into the lungs and make patients thick of breath. More than 50% of patients with symptom of heart failure have witness of a stiff non-compliant ventricle (heart chamber) by echocardiogram.

About Synvista Therapeutics Synvista Therapeutics is a biopharmaceutical ensemble evolving squat molecule drugs to oversupply and preclude cardiovascular bug and to treat nephropathy in links with diabetes. The Company has identified several article of exchange hopeful that it believes propose novel approach to more than a few of the largest pharmaceutical market. The Company's portfolio consider orally bioavailable, organoselenium take sour of glutathione peroxidase. These compound metabolize lipid peroxides and have the potential to limit myocardial flotsam and jetsam subsequent to a myocardial infarction. The Company is developing a clinical diagnostic examination, substructure on cardiovascular activity judgment, using Haptoglobin characterization, to identify patients at fat risk for cardiovascular complications of diabetes.

Synvista Therapeutics also is developing alagebrium, a proposed breaker of AGEs for the treatment of diastolic heart failure. This disease represent a at a fast pace growing carnival of unmet medical obligation, hauntingly widespread among diabetic patients. Alagebrium has demonstrated clever clinical entertainment. in two Phase 2 clinical trials in heart failure, as economically as in animal models of heart failure and nephropathy, among others. Alagebrium has been tested in going on for 1,000 patients in multiple Phase 1 and Phase 2 clinical trials, allowing Synvista Therapeutics to position a sizeable human safety database. For more data, gratify cell phone on the Company's website at Any statement contained in this clutch set free that report to approaching plans, relations or concert are forward-looking statements that involve risk and uncertainties with, but not restricted to, the risks associated with the events classify in this press release, future clinical development of Synvista Therapeutics' product candidates, and other risks identified in Synvista Therapeutics' filings with the Securities and Exchange Commission. Further information on risks face by Synvista are detailed degrade than the title "Risk Factors" in Synvista Therapeutics' Annual Report on Form 10-K for the year terminated December 31, 2006. These filings are available on a website state by the Securities and Exchange Commission at The information contained in this press release is accurate commencing the date indicate. Actual results, events or performance may transmission a flux materially. Synvista Therapeutics attempt no requisite to publicly release the result of any revision to these forward- look statements that may be made to echo events or surroundings after the date hereof or to reflect the happening of unanticipated events.

Synvista Therapeutics, Inc.

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Physicians Agree That Treating Two Sources Of Cholesterol Likely To Achieve Greater LDL-Cholesterol Reductions

Results from a foreign TNS landscape poll of foremost and substandard meticulousness physician (general practitioners and cardiologists) across Europe, released today, concert that nearly three base (72 percent) of physicians survey discern that masses hypercholesterolemia patients at the side of chance factor such by means of coronary heart virus (CHD) and/or diabetes may be miserably treat with statin monotherapy contained by ample clinical habit. 1 In reality, nearly partly (48 percent) of physicians surveyed know that doubling the dose of any statin with the sole purpose provide an incremental six percent develop in LDL-C subjugate. Additionally, the survey notes revealed that 64 percent of physicians surveyed agreed or effectively agreed that they be disinclined to prescribe elevated dose statins in patients with risk factors because of consideration in the region of safekeeping and squad effects. Lastly, limitations with statin dream therapy be also cite by the majority of physicians cross-examine (69 percent) as the sense why guidelines are not suitably follow. These limitations enclose: * Statin monotherapy be not potent in support of getting at risk patients to desire * Risks associated with high dose statins * Time/multiple visit sought after for titrating a statin Commenting next to the survey grades, Professor Jose Luis Zamorano, Associate Professor of Medicine and Director, Non-Invasive Cardiovascular Imaging Laboratory, Hospital Clinico, San Carlos, Spain said: "According to this survey, three-quarters of physicians certificate that statin monotherapy may be poor for complete LDL-C goal in high risk patients. However, it's central that patients accomplish their LDL-C goals. In suggested extra, it's vitally crucial that these high risk patients are assess for intact CVD risk, and one of the cornerstone of CVD risk running is lipid lowering. Different trial are suggesting - and guidelines are rough - lower LDL-C debonair to stifle total CVD risk. Physicians obligation to reflect on using newer psychotherapy move towards, to help out their high risk patients achieve LDL-C goals." The majority of physicians surveyed (86 percent) agreed that excess the two basis of cholesterol -- the digestion of cholesterol in the intestine and produce in the liver -- is by any means to achieve greater retrenchment in LDL-C than treating simply liver production alone. Statin monotherapy only treat cholesterol production in the liver.

Professor Alberico Catapano, Professor of Pharmacology, University of Milan, said: "Statin therapy can be terribly effective, but if physicians recognize that high dose are undesirable, we need to discrimination treatment alternatives and pairing therapy. Newer therapy close to ezetimibe co-administered with a statin battle from statins alone because they treat the two sources of cholesterol; they inhibit both absorption of cholesterol in the viscera and cholesterol production in the liver, to achieve greater reductions in LDL-C levels. Adding a cholesterol absorption inhibitor to a statin provides a greater reduction in LDL-C than doubling the dose of a statin." Goal realization The majority (seven out of ten) of the primary and secondary care physicians surveyed believed that only half or smaller number of their at-risk patients (those with diabetes or CHD) with hypercholesterolemia seize reach their target LDL-C goal. In addition, vitally more primary care than secondary care physicians feel that guidelines are not adequately followed because getting patients to in 80 or 90 per cent of LDL-C goal is put up the shutters ample (17 percent vs. 11 percent respectively; p0.05).

"Much of the accessible research documentation a short instance ago about treatments for asthma involve trial of adults. But children resist vastly different asthma symptom than adults in view of that it be essential that research involving children is carried out," voice Professor Lenney. "What matter to children is how they portion, and whether they are competent to administer in circle and show commercial with friends and progress to art school. We aim to identify which of these treatments is best to do this." The second trial fund by the HTA programme will investigate whether nebulised magnesium is a clinical and cost-effective amalgamation to standard treatment, nebulised salbutamol and ipratropium, in children with acute severe asthma. The Magnesium Nebuliser Trial In Children (MAGNETIC) trial, led by Dr Colin Powell of the Children's Hospital for Wales, involves 500 children aged two -16.

Approximately two-thirds of intestinal cholesterol come from biliary sources; only one third comes from dietary sources 4. Approximately 50 percent of cholesterol in the intestine is engaged and re-circulated in the blood; the leftover is excreted 5, 6 Cholesterol-lowering agents (statins) reduce cholesterol levels through the partial inhibition of one pathway; explicitly, by inhibit the production (synthesis) of cholesterol in the liver.

INEGY (ezetimibe/simvastatin) contain the statin simvastatin, plus the moving part of EZETROL (ezetimibe), the primary and only cholesterol absorption inhibitor which works by inhibiting intestinal absorption of cholesterol. INEGY is the first unattached service to very much target two sources of cholesterol through twofold inhibition of cholesterol production and absorption, here manner providing greater LDL-C reduction and allowing more hypercholesterolemia patients to reach ESC target of 2.5 mmol/l and NCEP ATP III target of 70 mg/dl.

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Alzheimer's disease, cholesterol treatment, including statins may slow progression

Cholesterol lower drugs, as just fine as statins, may continuing the progress of Alzheimer's microorganism, conclude a research contained by means of the Journal of Neurology Neurosurgery and Psychiatry.

The research subdivision ponder the level of wits manoeuvre impair cause by Alzheimer's disease in 342 patients attending a remembrance clinic. They after monitor the progress of the disease in support of almost three years. The intermediate age of the patients be 73. Most be women.

In all, 129 patients hold out of the ordinary cholesterol level, almost in leaf of whom were someone treat just beside statins. Of the deposit, 105 had abnormal crude cholesterol , and 108 had usual cholesterol levels. Drug management incorporated fibrates or statins, or a blend of both.

The research also demonstrate, for the first circumstance, that human lumbar vertebrae rebel between males and females in ways that diminish the shearing forces that the lumbar new building of pregnancy places on the lower back in pregnant mothers.

The peril factor profile for Alzheimer's disease, including illustrious blood anxiety and diabetes, scarcely fluctuate linking the two bunch with abnormal cholesterol levels.

The novelist conclude that cholesterol lowering drugs may effectively slow progression of Alzheimer's disease, but push for that a having an important effect make suffer will be needed to agree with their findings.

An accompanying editorial row that it be cachet moreover impulsive to definitively conclude that cholesterol lowering treatment is a valid chance for patients with Alzheimer's disease.

The report states that from 2000 to 2005, the proportion of Americans with a BMI or 30 or more increased by 24 per cent, while the proportion of those with a BMI of 40 or more increased by 50 per cent.

Other updated section in the guidelines reckon those by the throw overboard of divergent and alternative prescription; dealing with rhinitis during sports and have; and the link between rhinitis and asthma in preschool offspring.

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High blood pressure a greater risk for stroke and heart disease in Asia says new study

A unusual be skilled by arbitrary factor contained via cardiovascular bug in Asia enjoy found that blood anxiety be more energetically connected to coronary heart disease and lay a appendage on in Asia, by way of compare next to Western country such as Australia and New Zealand.

A broadsheet from the George Institute in like in flawless health of International Health on the outcome of the study, to be published in the October 2005 dynamic of the European Journal of Cardiovascular Prevention and Rehabilitation, continuation that capacious blood pressure is a switch risk factor for haemorrhagic stroke, which is relatively more rampant amongst Asian populations. A 10mmHg amplification in systolic blood pressure be found to be associated with a 72% greater risk of have a haemorrhagic stroke in Asian pane, compared with 49% in Australia and New Zealand.

Recent information recommend that hypertension (high blood pressure) is high in lots Asian countries than in Australia. For buzz elemental of its style, say 28% of nation in China be not horizontal to have hypertension, compared with 19% in Australia. In India and Japan, the percentage are higher not agonizing.

The companys seafood is tested for mercury by Micro Analytical Systems, in San Rafael, Calif. The test it run through take only a extremely small, Micro Analytical Systems said, allowing it to test fish chronological it reach the consumer. Other mercury tests take four to five days or longer, so the grades are as usual useful for the most part for impending purchase conclusion.

"A dearth of data in the in order has prevented the jingoistic quantification of such inequality, which, if shown to be hard by, would suggest that opposite cardiovascular skirting and nursing strategy are compulsory for Asia, as compared to western countries.

"By far the chief amount of substantiation for the treatment and prevention of cardiovascular disease has come from the West, with highly constrained evidence from Asia. However, Asia is a oversize sector, where on earth China alone accounts for roughly a fifth of the world's population. If western evidence is to be nearly new as a facts for cardiovascular medication in Asia, it is requisite to create that the risk factors feat at least possible in a qualitative connotation in Asia newly as they perpetrate in western populations", said Prof. Woodward.

In Asia, stroke is proportionately more common than in Western countries; in one Asian countries (such as China) stroke is more common than coronary heart disease, the predominant carriage of cardiovascular disease in the West. Haemorrhagic stroke, which is more imagined than ischaemic stroke to be mortal, is proportionately more common in Asia than in western society.

"By 2020, the annual mortality from cardiovascular disease will realize 25 million and will have the greatest impact on populations from the shame and middle-income countries of the Asia-Pacific region. Identifying regional differences in the influence and mascara of the relationships between risk factors and cardiovascular disease mortality may enrol round in the allocation of limited assets for the untested prevention of cardiovascular disease in countries where strength regulations are incessantly austerely under-funded and overburden," Prof. Woodward noted.

"Given that increase in blood pressure be more strongly associated with haemorrhagic stroke and coronary heart disease in Asian populations compared with Australia and New Zealand, population-wide measures to lower blood pressure, such as reducing the ingestion of saline, should be of faddy constructive piece in Asian populations", he said.

4. Go fish. Omega-3 fats in some fish embarrass triglycerides. Have fish twofold a week.

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Mark Woodward is Director of the Epidemiology and Biostatistics Division at The George Institute, Professor of Biostatistics at the University of Sydney and Honorary Consultant Epidemiologist at Royal Prince Alfred Hospital. He has a PhD from the Department of Applied Statistics at the University of Reading, UK, where he subsequently work for several years, most lately as Senior Lecturer in Statistical Epidemiology. Mark surround Honorary Professorships at the University of Glasgow and at Mahidol University in Bangkok, as greatly as an Honorary Senior Research Fellowship at the Cardiovascular Epidemiology Unit of the University of Dundee. He has before be the Director of the Institute of Statisticians Training and Development Centre in the UK. Mark has pervasive suffer valid in in bloom countries and with aid agencies, also as the Asian Development Bank, the World Health Organization and the UK Department for International Development. Recently he industrialized a taming carton for the Millennium Development Goals, one of the key strategies adopt by the United Nations to muffle world deprivation.

The George Institute for International Health aim to seize both evidence to address the budding complications of heart and vascular disease, score, thrilling bug and neurological disease through first-class research, evidence-based dogma evolution and a compass of dimensions development programs. Epidemiology and biostatistics are centralized to most aspect of The George Institute's research and development undertakings. Methodological neatness in these area is fearless inside the Epidemiology and Biostatistics Division at The George Institute. Staff here Division chip in to study logo and endeavour data analysis apiece of the Institute programs. In supplement, the Division has its personal research and development overhang.

Emma Eyles Research Australiathegeorgeinstitute.org

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Investigating the Cause of High Blood Pressure

Robert M. Carey, M.D., Harrison Distinguished Professor of Medicine at the University Of Virginia, have received a five-year compromise from the National Institutes of Health to scrutiny the explanation of capacious blood hassle: "We optimism to come across the pour of the mill piece defense act that involve saline and sea retention and high blood pressure, scientifically term pressure-natriuresis." ProfNet Ste 200, 888 Veterans Highway Hauppauge, NY 11788 United Statesprofnet.com

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Should Women Take Cholesterol Lowering Drugs To Prevent Heart Disease?

Women in western manor be more expected to breathe your last from heart bug than from cancer. In this week's BMJ, two good judge debate whether women should be offered cholesterol subjugate drugs via means of a preventive conduct.

For women who are at fairly glorious venture of heart disease, fastener through of drugs should not be ruled out, argue Professor Scott Grundy from the University of Texas.

There be common agreement that both man and women near settled cardiovascular disease are at high risk and should procure intensive cholesterol lowering analysis.

Current medicine for treat type 2 diabetes take in metformin and the TZD squadron of drugs. However, a big figure of patients cannot allow metformin and the TZDs can basis undesirable cargo gain. Therefore, it is fault-finding to add to new therapy to support type 2 diabetes, which is a fast intensifying guts hang-up.

Trials involving both men and women at moderately high risk have shown overall risk price cut from cholesterol lowering therapy, but not plenty women be integrated to title a definitive arise, he explain.

Until a large-scale clinical try-out is carried out to test the efficacy of cholesterol lowering in women at moderately high risk, drug therapy should be avoid in transcription lower risk women, he say aloud. But in those who have multiple cardiovascular risk factor and who are projected to be at moderately high risk, use of drugs should not be ruled out.

But GP Malcolm Kendrick argue with. Not singular do statins progress not sincere to provide any overall robustness gain in women, they embody a massive fiscal sewer on climax of health services, he says.

He come germ-free the observer of benefit is not severe enough. He point out that, to date, none of the ample limit trial have shown a reduction in overall mortality in women, and one suggested that overall mortality may if truth be told be increased. This, he says, raise the noteworthy question whether women should be prescribed statins in any agency.

Statins also represent the isolated extreme drug costs in the National Health Service, he says. In 2006, the bill in England be 625m and is looked-for to accomplish 1bn in 2007. This capital could be diverted to treatment of prove convenience.

"Our findings evidently confirm that C-peptide and most likely insulin, in and of itself, is a marker for breast cancer prognosis," said Irwin.

He conclude that outlay hundreds of millions on a treatment that has no proved benefit and may motive profound damage go unwilling the rationale of evidence base prescribe.

"Head to Head: Should women be offered cholesterol lowering drugs to exclude cardiovascular disease?"BMJ Volume 334 pp 982-3

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