Should Women Take Cholesterol Lowering Drugs To Prevent Heart Disease?

Women in western manor be more expected to breathe your last from heart bug than from cancer. In this week's BMJ, two good judge debate whether women should be offered cholesterol subjugate drugs via means of a preventive conduct.

For women who are at fairly glorious venture of heart disease, fastener through of drugs should not be ruled out, argue Professor Scott Grundy from the University of Texas.

There be common agreement that both man and women near settled cardiovascular disease are at high risk and should procure intensive cholesterol lowering analysis.

Current medicine for treat type 2 diabetes take in metformin and the TZD squadron of drugs. However, a big figure of patients cannot allow metformin and the TZDs can basis undesirable cargo gain. Therefore, it is fault-finding to add to new therapy to support type 2 diabetes, which is a fast intensifying guts hang-up.

Trials involving both men and women at moderately high risk have shown overall risk price cut from cholesterol lowering therapy, but not plenty women be integrated to title a definitive arise, he explain.

Until a large-scale clinical try-out is carried out to test the efficacy of cholesterol lowering in women at moderately high risk, drug therapy should be avoid in transcription lower risk women, he say aloud. But in those who have multiple cardiovascular risk factor and who are projected to be at moderately high risk, use of drugs should not be ruled out.

But GP Malcolm Kendrick argue with. Not singular do statins progress not sincere to provide any overall robustness gain in women, they embody a massive fiscal sewer on climax of health services, he says.

He come germ-free the observer of benefit is not severe enough. He point out that, to date, none of the ample limit trial have shown a reduction in overall mortality in women, and one suggested that overall mortality may if truth be told be increased. This, he says, raise the noteworthy question whether women should be prescribed statins in any agency.

Statins also represent the isolated extreme drug costs in the National Health Service, he says. In 2006, the bill in England be 625m and is looked-for to accomplish 1bn in 2007. This capital could be diverted to treatment of prove convenience.

"Our findings evidently confirm that C-peptide and most likely insulin, in and of itself, is a marker for breast cancer prognosis," said Irwin.

He conclude that outlay hundreds of millions on a treatment that has no proved benefit and may motive profound damage go unwilling the rationale of evidence base prescribe.

"Head to Head: Should women be offered cholesterol lowering drugs to exclude cardiovascular disease?"BMJ Volume 334 pp 982-3

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