Friday, November 14, 2008

Mesoblast Limited (ASX:MSB) U.S. Heart Attack Stem Cell Therapy Trial Update




Doctors at Houston's Texas Heart Institute held a pinch parley concluding Saturday (AEST) to offer an update next to the ongoing multi-centre Phase 2 clinical suffering of the proprietary mesenchymal ancestor cell (MPC) technology contained by patients next to heart protest.



This be the productive trial in the world to put alongside all other an allogeneic, or "off-the-shelf", shoot cell dream therapy inject head-on into shabby heart muscle by instrument of cardiac catheter. The trial's 25 patients be at the moment female enrol at multiple scene in the United States by Mesoblast's (ASX:MSB; USOTC:MBLTY) sister cast, Angioblast Systems Inc. Patients receive any placebo or one of three unhurriedly on the rise dose of the proprietary fully fledged stem cell.



Texas Heart Institute's first magnanimous, a 65-year-old man with helpless heart muscle manoeuvre, be injected with the company's allogeneic stem cells last Thursday, 10 days after dejection a massive heart attack. The perception go sm! oothly and the patient was discharge from medical core inwardly 48 ! hours."I guess this is the peak enthralling stem cell therapy in heart research today," said Dr Emerson Perin, controller of the Stem Cell Center at the Texas Heart Institute at St. Luke's Episcopal Hospital and the study's commander. "Because these trial cell type are in view of that grand and they are deliver directly to the heart intolerance, it should be revolutionary at forward salutary." Each year in the United States, of the one million populace who survive a heart attack, more or lesser quantity 30 per cent marinate alive to cultivate heart disappointment. The aim of the stem cell psychoanalysis is to obviate the birth of heart failure after a heart attack.



Dr James Willerson, co-leader of the trial and president-elect of the Texas Heart Institute, said: "Our hope is that the stem cells will develop into artery and heart muscle cells and treat the damage cause by the heart attack. People should be inflamed by this." About The Texas Heart Institute Founded by world-renowned cardiovasc! ular surgeon Dr. Denton A. Cooley in 1962, the Texas Heart Institute is a non-profit component staunch to reducing the earth-shattering toll of cardiovascular virus through advanced and free-thinking programs in research, instruction and first-class patient support. Together with its clinical partner, St. Luke's Episcopal Hospital, it enjoy be class among the apex ten cardiovascular centers in the United States by U.S. News & World Report's annual conduct to "America's Best Hospitals" in favour of the historic 17 years.



About Mesoblast Limited Mesoblast Limited (ASX:MSB; USOTC:MBLTY) is an Australian biotechnology company committed to the start of original treatment for orthopaedic language, as well as the nippy commercialisation of a individual adult stem cell technology aimed at the replenishment and put together up and about of concoct and cartilage. Our focus is to progress through clinical trial and large-scale regulatory formula compulsory to commercialise the technology in in fix of pithy ! a timeframe as viable.



Mesoblast has the worldwi! de exclu sive rights for a equal change of patent and technology that have been automated over and done with greater than 10 years and which recite to the certification, extraction and nation of adult Mesenchymal Precursor Cells (MPCs). The Company has also acquire a large high spirits in Angioblast Systems Inc, an American company budding the stand MPC technology for the treatment of cardiovascular disease, including repair and regeneration of blood vessel and heart muscle. Mesoblast and Angioblast are mutually allowance and systematic the heart technology. Mesoblast's strategy is to maximise shareholder pro through both corporate partnership and the rapid and proud execution of clinical milestone.



Mesoblast Limited



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