Vaccine To Treat High Blood Pressure Could Be On The Way Part 2

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The researchers treat 72 patients (65 man and 7 women) next to category to have a rest soaring blood constraint by means of inject them three times with 100 or 300 micrograms of vaccine or placebo. The immunisation be done at the begin of the gain knowledge of (week zero), and anon at week 4 and again at week 12. They measured the blood pressure change at week 14. The intermediate age of the patients be 51.5 years.

After the injections, the patients in the vaccine sect have a stringent antibody riposte in opposition angiotensin II, and this response was a great traffic stronger in the patients who had the dense dose.

For the patients who were given the 300 microgram vaccine injections (the higher dose), their daytime systolic blood pressure (the higher of the two reading, taken as the heart constricts) was 5.6 mm of mercury (mm Hg) belittle than that of the placebo group. Their diastolic blood pressure (the lower of the two readings, taken when the heart relax linking beats) was 2.8 mm Hg lower than the placebo group's.

Senior co-author of the study and chief incontestable officer at vaccine developer, Cytos Biotechnology AG in Zurich, Switzerland, Dr Martin Bachmann said: "Quite unexpectedly, our vaccine had the supreme striking effect impulsive in the morning, the most death-defying happening to enjoy high blood pressure because it raise the hazard of heart storming and pat." The researchers found that the 8 am systolic blood pressure was 25 mm Hg lower and the diastolic was 13 mm Hg lower in the 300 microgram vaccine group than the placebo group.

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This compare with conventional pills therapy where on dirt medication is at its lowest rank in the blood flush at this suggestible time in the morning because it is only just past general public take their dose for the daylight.

Another potential advantage the vaccine have complete drugs is that they enlargement level of the enzyme renin, which mete out inflammation and is invent to increase risk of kidney bomb, whereas the vaccine only cause a fabulous increase in renin, said the researchers.

The researchers intend to test the vaccine in another slender study to discern if a dissimilar dosage rundown causes a greater antibody response and can further drain blood pressure.

adults have high blood pressure. About one-third of them overtake not know they savour it. Uncontrolled high blood pressure can lead to stroke, heart attack, heart dud or kidney failure.